Last edited by Shakajinn
Saturday, February 8, 2020 | History

4 edition of Anion receptor chemistry found in the catalog.

Anion receptor chemistry

Jonathan L Sessler

Anion receptor chemistry

  • 132 Want to read
  • 33 Currently reading

Published by Royal Society of Chemistry in Cambridge .
Written in English

    Subjects:
  • Anions -- Receptors,
  • Supramolecular chemistry

  • Edition Notes

    Includes bibliographical references and index

    StatementJonathan L. Sessler, Philip A. Gale, Won-Seob Cho
    SeriesMonographs in supramolecular chemistry
    ContributionsGale, Philip A, Cho, Won-Seob
    The Physical Object
    Paginationxv, 413 p. :
    Number of Pages413
    ID Numbers
    Open LibraryOL17196916M
    ISBN 100854049746

    These initial findings point the way to more effective systems involving receptors with higher selectivity, binding strength, and solubility. Salt bridges have been used by chemists within this field in both diverse and creative ways, including sensing of anions, the synthesis of molecular capsules and double helical polymers. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. The midpoint of the titration curve corresponds to the pKa, or the pH where the ratio of protonated:deprotonated molecules is This allows beta carboline to act as an inverse agonist and reduce the current below basal levels. Molecular capsules[ edit ] Molecular capsules are chemical scaffolds designed to capture and hold a guest molecule see molecular encapsulation.

    Entropy plays a larger role in surface salt bridges where residues that normally have the ability to move are constricted by their electrostatic interaction and hydrogen bonding. Figure 5 shows a pKa of the wild-type of 9. A salt bridge in T4 lysozyme between aspartic acid Asp at residue 70 and a histidine His at residue 31 The contribution of a salt bridge to the overall stability to the folded state of a protein can be assessed through thermodynamic data gathered from mutagenesis studies and nuclear magnetic resonance techniques. Figure 8.

    Self-assembly of a double helical metallopolymer. The midpoint of the titration curve corresponds to the pKa, or the pH where the ratio of protonated:deprotonated molecules is This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry, while illustrating the basic approaches currently being used to effect receptor design. Receptor antagonists can be competitive or reversibleand compete with the agonist for the receptor, or they can be irreversible antagonists that form covalent bonds or extremely high affinity non-covalent bonds with the receptor and completely block it.


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Anion receptor chemistry book

He has edited an enormous range of seminal works in supramolecular chemistry including the fi ve-volume series Inclusion Compounds and and the volume Comprehensive Supramolecular Chemistry Figure 8.

Theories of drug-receptor interaction[ edit ] Occupation[ edit ] The central dogma of receptor pharmacology is that a drug effect is directly proportional to the number of receptors that are occupied. In the unfolded wild-type protein, where the salt bridge is absent, His31 is reported to have a pKa of 6.

Not every ligand that binds to a receptor also activates that receptor. Figure 5 shows the shift in the titration curve between the wild-type and the mutant in which Asp70 is Asn. They also highlight briefly some of the features that are present in naturally-occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry.

Entropic driving forces for ion pairing in absence of significant H-bonding contributions are also found in methanol as solvent. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible.

From the book series:. More information. This arrangement produces an economy of neurotransmitter production and release. Language: English. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible.

Receptor sequestration internalization. This is a locally acting feedback mechanism. He carried out graduate research with Galen Stuckey at the University of Illinois, where he obtained his Ph.

Anion complexation[ edit ] Major contributions of supramolecular chemistry have been devoted to recognition and sensing of anions.

Publications

When the salt bridge is disrupted, like in the mutant D70N, the pKa shifts back to a value of 6. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art.

One method involves the observation of the melting temperature of the wild-type protein versus that of the three mutants. Figure 4.

There are also LGICs for at least a dozen endogenous ligands, and many more receptors possible through different subunit compositions. Figure 7. The following classes of ligands exist: Full agonists are able to activate the receptor and result in a strong biological response.

The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. Titration curve between the wild-type blue and the mutant red The second method utilizes nuclear magnetic resonance spectroscopy to calculate the free energy of the salt bridge.

Thus, that system has spare receptors or a receptor [email protected]{osti_, title = {Supramolecular Chemistry of Selective Anion Recognition for Anions of Environmental Relevance}, author = {Bowman-James, Kristen}, abstractNote = {This project have focuses on the basic chemical aspects of anion receptor design of functional pH independent systems, with the ultimate goal of targeting the selective binding of sulfate, as well as design of.

An important contribution from anion receptor chemistry is the utilization of metal-free anion binding receptor to direct catalysis, and the use of thiourea-based Cited by: Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world.

Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a Cited by: Jan 19,  · Abstract.

Metal complexes play an important role in anion receptor chemistry.

Salt bridge (protein and supramolecular)

In the majority of examples metal centres are used as optical and/or electrochemical reporter groups in anion-sensing sylvaindez.com by: Get this from a library! Anion receptor chemistry. [Jonathan L Sessler; Philip A Gale; Won-Seob Cho] -- Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world.

Chemists working in the area of. Building on the pioneering work in supramolecular chemistry from the last 20 years or so, this monograph addresses new and recent approaches to anion coordination chemistry.

Synthesis of receptors, biological receptors and metallareceptors, the energetics of anion binding, molecular structures of anion complexes, sensing devices are presented and computational studies addressed to aid with the.